Tommy Kahnle responded by hitting Miguel Cabrera of the Tigers.
On the Yankees' side, Sanchez, who was spotted punching Cabrera while he was in the middle of the melee, received a four-game suspension and Romine got a two-game ban.
Both benches cleared, and eight players or managers were ejected by the time the Tigers finished off a 10-6 victory.
The bad blood from these two teams likely carried over from their meeting last month when Kahnle hit Detroit's Mikie Mahtook in the head with a 98-mph fastball, though the first two games of this series showed no signs of any eruption like fans witnessed today.More news: Increasing Vitamin C Intake Cuts Blood Cancer Risk
Detroit cleanup hitter and 11-time All-Star Miguel Cabrera and NY catcher Austin Romine were tossed after a sixth-inning brawl.
Five players were ejected, along with managers Joe Girardi of the Yankees and Brad Ausmus of Detroit, and NY bench coach Rob Thomson. Something was said between Cabrera and catcher Austin Romine, though it's not clear what.More news: Taylor Swift reveals release date and cover art for new LP 'Reputation'
"I was actually on the field, so I haven't seen it, I haven't talked to them about it", Tigers manager Brad Ausmus said when asked about Verlander/Martinez incident, the Detroit Free Press reports.
On Thursday, the Yankees-Tigers brawl in Detroit lit up the internet. "I was cool with that", Cabrera said.
Tigers reliever Alex Wilson was immediately ejected after hitting Clint Frazier in the thigh with a pitch in the top of the eighth. When I got back to home plate, I tell him, 'You got any (bleeping) problem with me?' He said, 'Why?' I said because I try to calm (things) down and you try to act tough.
There, Castellanos got punched, by his count, five times, including once from Gary Sanchez, whose sucker-punch game seems to match his power game. He delivered a single that scored Gardner to cap the Yankees' three-run rally and tie the score at 6-6 in the seventh. Betances was ejected and the benches cleared again.More news: Walmart Teams With Google On Voice Activated Shopping
Justin Upton and James McCann homered for Detroit, and Gary Sanchez went deep for the Yankees, but that all became secondary on a day when the umpires had their hands full trying to maintain order.