Nadal also paid an emotional tribute to his uncle and lifelong coach Toni Nadal, who will step aside from his role at the end of the season.
Winners are normally given a small trophy to keep.
Nadal clutches the trophy.
Playing in his 22nd Grand Slam final, Nadal triumphed in Paris without dropping a set for a third time.
Nadal hailed the French Open as the most special tournament for him.
Swiss third seed Wawrinka was trying to win his second Roland Garros title in three years but was blown away by Nadal 6-2, 6-3, 6-1.More news: Israel approves over 8000 new West Bank Housing units
A 6-2 6-3 6-1 straight-sets dismantling of Stan Wawrinka saw Nadal complete "La Decima" on Sunday, an unprecedented 10th grand slam, three injury-plagued years after the 31-year-old claimed his last.
Defeat by Austria's Dominic Thiem in Rome was a minor blip as Nadal went on to enjoy total domination at Roland Garros, emulating his 2008 and 2010 titles when he did not drop a set.
With the win, Nadal extended his head-to-head lead over Wawrinka to a stellar 16-3, and improves to a flawless 10-0 in French finals.
Nadal converted an incredible six of his 13 break point opportunities over the course of the three sets. He won all 12 service games, saving the lone break point he faced, and made a mere 12 unforced errors.
Nadal immediately put Wawrinka in the same position on the next game.
And Wawrinka was quick to acknowledge that he simply could not live with Nadal, who will rise to second in the world rankings as a result, as he addressed him after the match.More news: Alonso "will stay" at McLaren if it wins by September
The men's tennis world seems to have gone back to 2012.
It is the most singles titles one person has won at a Grand Slam.
That started when Nadal broke the Swiss in the sixth game, and after wrapping up the set he opened up a 3-0 lead in the second that would prove decisive.
Mattek-Sands and Safarova were also champions at this year's Australian Open.
For Stan Wawrinka, the effect of seeing Rafael Nadal across the other side of the net with that Roland Garros clay under his feet was overwhelming.
The sun is shining, there is barely a trace of cloud in the sky and the temperature is about 85 degrees (30 Celsius) as Sunday's title match approaches. Time and again, when Wawrinka did hit out, he missed, and when he didn't, Nadal was there to rip a victor after winner.More news: South Africa : West coast storm kills 8, causes chaos
No other man or woman has won 10 championships at the same major in the Open era, which began in 1968.